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Obesity research targets the brain's use of fatty acids
"This work may have important impact in understanding the causes of obesity and providing new therapys for this epidemic of our time," said Robert H. Eckel, MD, corresponding and senior author of "Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity" which was published recently in Cell Metabolism.
The genetically-modified mouse (NEXLPL) has a defect in the breakdown of dietary lipoprotein triglycerides into fatty acids in the brain. These mice became obese on a standard chow diet between three and six months. At that point, the mice ate less and were less active.
The research also looked at which areas of the brain have the greatest impact on regulating body weight and learned that the hypothalamus appears to be the key area to observe as NEXLPL mice have increases in hypothalamic AgRP/NPY gene expression before obesity. AgRP/NPY cause increases in food intake and decreases in energy expenditure. Scientists also noted that the NEXLPL mice demonstrate deficiencies in n-3 fatty acids in the hypothalamus. Overall, this research indicates that the lipoproteins are sensed in the brain by an LPL-dependent pathway and provide lipid signals for the central regulation of body weight and energy balance.
The research team included researchers in the Division of Endocrinology, Metabolism and Diabetes in the Department of Medicine at the CU School of Medicine; the Department of Pharmacology at the University of California Irvine; the Department of Neurogenetics at the Max-Planck-Institute of Experimental Medicine in Gera number of; the Italian Institute of Technology in Genoa, Italy and the Department of Medicine at Columbia University in New York.
Faculty at the University of Colorado's School of Medicine work to advance science and improve care. These faculty members include physicians, educators and researchers at University of Colorado Hospital, The Children's Hospital, Denver Health, National Jewish Health, and the Denver Veterans Affairs Medical Center. Degrees offered by the University of Colorado School of Medicine include doctor of medicine, doctor of physical treatment, and masters of doctor assistant studies. The School is located on the University of Colorado's Anschutz Medical Campus, one of four campuses in the University of Colorado system. For additional news and information, please visit the UC Denver newsroom online.
Posted by: Evelyn Source